Hypoplastic Left Heart

Hypop bearic 1 Running Head: HYPOPLASTIC LEFT HEART SYNDROME Hypoplastic remaining field breast Syndrome Hypoplastic 2 Hypoplastic left(p) heart syndrome (HLHS) is congenital abnormality in which the left grimace of the heart is severely underdeveloped. It is often associated with mitral atresia, aortal atresia, or some(prenominal) (http://www.accessmedicine.com, 2008). When the left-side heart structures are underdeveloped, the expand side of the heart must pump blood to both the lungs and to the quiet of the body. In HLHS, pulmonary venous blood enters the left atrium notwithstanding systole is unable to push the blood across the constricted or absent mitral valve into the left ventricle. The blood kinda is shunted into the right atrium through the PDA, where it contributes to volume loading of the right ventricle. The ratiocination military issue is pulmonary venous hypertension, right v entricular failure, and profound underperfusion of coronary thrombosis arteries and vital organs (http://www.accessmedicine.com, 2008). Despite funny advances in the diagnosis and treatment of HLHS, it remains one of the more or less therapeutically gainsay and least-understood forms of congenital heart disease. HLHS is a antiquated defect, occurring in 0.016%-0.

036% of function births (Bove, 2002). However, it continues to be the leading cause of infant death callable to cardiovascular malformation (CVM) and is associated with significant long-term morbidity (JACC, 2007). During the last 50 ye ars there has been change magnitude evidenc! e that supports a genetic etiology for HLHS. In the journal of the American College of Cardiology, Hinton et al performed a study to determine the sizing of heritability in families set by a HLHS proband. They found that HLHS was most exclusively the resolution of a genetic cause. Fifty-five per centum of the families had 1 or more affected family members and rate among siblings was 8%. xxii percent of the siblings also had an additional CVM....If you want to get a blanket(a) essay, order it on our website: OrderCustomPaper.com

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